近期研究成果

子題1-1 開發新穎性抑制劑用於癌藥抗藥性

1 Cheng YB, Chien YT, Lee JC, Tseng CK, Wang HC, Lo IW, Wu YH, Wang SY, Wu YC, Chang FR. Limonoids from the Seeds of Swietenia macrophylla with Inhibitory Activity against Dengue Virus 2. J Nat Prod. 2014;77:2367-74.
2 Chung HM, Wang WH, Hwang TL, Li JJ, Fang LS, Wu YC, Sung PJ. Rumphellaones B and C, new 4,5-seco-caryophyllane sesquiterpenoids from Rumphellan antipathies. Molecules, 2014;19, 12320-7.
3 Chung HM, Wang WH, Hwang TL, Chen JJ, Fang LS, Wen ZH, Wang YB, Wu YC, Sung PJ. Rumphellols A and B, New Caryophyllene Sesquiterpenoids from a Formosan Gorgonian Coral, Rumphella antipathies. Int J Mol Sci. 2014;15: 15679-88.
4 Juan YS, Lee CC, Tsao CW, Lu MC, El-Shazly M, Shih HC, Chen YC, Wu YC, Su JH. Structure elucidation and cytotoxic evaluation of new polyacetylenes from a marine sponge Petrosia sp. Int J Mol Sci. 2014;15:16511-21.
5 Kuo CY, Juan YS, Lu MC, Chiang MY, Dai CF, Wu YC, Sung PJ. Pregnane-type steroids from the Formosan soft coral Scleronephthya flexilis. Int J Mol Sci. Int J Mol Sci. 2014;15:10136-49.
6 Lee CL, Hwang TL, Yang JC, Cheng HT, He WJ, Yen CT, Kuo CL, Chen CJ, Chang WY, Wu YC. Anti-Inflammatory Spirostanol and Furostanol Saponins fromSolanum macaonense. J Nat Prod. 2014; 77: 1770-83.
7 Shih HC, El-Shazly M, Juan YS, Chang CY, Su JH, Chen YC, Shih SP, Chen HM, Wu YC, Lu MC. Cracking the cytotoxicity code: apoptotic induction of 10-acetylirciformonin B is mediated through ROS generation and mitochondrial dysfunction. Mar Drugs. 2014;12:3072-90.
8 Su Y.D, Cheng CH, Chen WF, Chang YC, Chen YH, Hwang TL, Wen ZH, Wang WH, Fang LS, Chen JJ, Wu YC, Sheu JH, Sung PJ, Briarenolide J. The first 12-chlorobriarane diterpenoid from an octocoral Briareum sp. (Briareidae). Tetrahedron Lett. 2014;55: 6065-7.

 

子題1-2 樺木酸衍生物做為抗乳癌藥物之活性評估與機制探討

 

子題1-3 從中藥中發現對抗“人類惡性腦膠質瘤"標靶新藥-從基礎研究到臨床試驗

1 Harn HJ, Chuang HM, Chang LF, Huang AY, Hsieh ST, Lin SZ, Chou CW, Kuo YH, Chiou TW. Taiwanin A targets non-steroidal anti-inflammatory drug-activated gene-1 in human lung carcinoma. Fitoterapia. 2014;99:227-35.

 

子題1-4 發展可影響選擇性剪接及表觀基因之中草藥及其機制的探討

 

子題1-6 從天然植物尋找抗發炎及細胞毒成分(含牛樟芝研發)

1 Tsai, T. C., Y. T. Tung, Y. H. Kuo, J. W. Liao, H. C. Tsai, K. Y. Chong, H. L. Chen, C. M. Chen. 2015. Anti-inflammatory effects of Antrodia camphorata, a herbal medicine, in a mouse skin ischemia model, J. Ethnopharmacol., 159, 113-121.
2 Kumar, K. J. S., J. Li, M. G.. Vani, Y. H. Hsieh, Y. H. Kuo, S. Y. Wang. 2015. Bornyl Cinnamate Inhibits Inflammation-Associated Gene Expression in Macrophage Cells through Suppression of Nuclear Factor-κB Signaling Pathway, Planta Med., 81, 39-45.
3 Ho, S. T., Y. T. Tung, Y. H. Kuo, C. C. Lin, J. H. Wu. 2015. Ferruginol Inhibits Non-small Cell Lung Cancer Growth by Inducing Caspase-associated Apoptosis, Integr. Cancer Ther. 14(1), 86-97.
4 Lien, J. C., C. C. Huang, T. J. Lu, C. H. Tseng, S. Y. Wang, H. Z. Lee, B. Y. Bao, Y. H. Kuo*, T. L. Lu*. 2015. Naphthoquinone derivative PPE8 induces endoplasmic reticulum stress in p53 null H1299 cells, Oxid. Med. Cell Longev., 2015, 1-10, doi.org/10.1155/2015/453679.
5 Chang, C. I., Y. C. Li, C. S. Yang, C. Y. Chao, Y. J. Li, H. S. Chang, C. J. Huang, C. C. Kuo, Y. H. Kuo*. 2015. Two New Labdane-Type Diterpene Acids from the Wood of Cunninghamia konishii, Helv. Chim. Acta., 98, 123-127.
6 Wang, Y. W., C. T. Yang, Y. H. Chen, C. L. Gong, Y. F. Chen, Y. H. Kuo*, Y. M. Leung. 2014. Inhibitory effects of imperatorin on voltage-gated K+ channels and ATP-sensitive K+ channels, Pharmacol. Rep., 67, 134-139.
7 Pan, C. H., W. H. Lin, Y. C. Chien, F. C. Liu, M. J. Sheu, Y. H. Kuo*, C. H. Wu. 2015. K20E, an oxidative-coupling compound of methyl caffeate, exhibits anti-angiogenic activities through down-regulations of VEGF and VEGF receptor-2, Toxicol. Appl. Pharm., 282(2), 215-226.
8 Chuang, S. T., Y. H. Kuo, M. J. Su. 2015. KS370G, a caffeamide derivative, attenuates unilateral ureteral obstruction-induced renal fibrosis by the reduction of inflammation and oxidative stress in mice, Eur. J. Pharmacol., 750, 1-7. 
9 Chao, L., C. H. Lin, H. W. Chiu, W. T. Wong, H. W. Chiu, Y. L. Tasi, Y. H. Kuo, Y. C. Chiu, M. L. Liu, C. L. Ho, K. F. Hua. 2015. Peroxyauraptenol inhibits inflammation and NLRP3 inflammasome activation by inhibiting reactive oxygen species generation and preserving mitochondrial integrity, J. Agric. Food Chem., 63(4), 1210-1219
10 Tsai, C. F., Y. H. Kuo*, W. L. Yeh, C. Y. J. Wu, H. Y. Lin, S. W. Lai, Y. S. Liu, L. H. Wu, J. K. Lu, D. Y. Lu *. 2015. Regulatory effects of caffeic acid phenethyl ester on neuroinflammation in microglial cells, Int. J. Mol. Sci., 16, 5572-5589.
11 Kuo, Y. H., C. H. Lin, C. C. Shih. 2015. Ergostatrien-3β-ol from Antrodia camphorata Inhibits Diabetes and Hyperlipidemia in High-Fat-Diet Treated Mice via Regulation of Hepatic Related Genes, Glucose Transporter 4, and AMP-Activated Protein Kinase Phosphorylation, J. Agric. Food Chem., 63(9), 2479-2489
12 Chen, J. J., C. K. Yang, Y. H. Kuo*, T. L. Hwang, W. L. Kuo, Y. P Lim, P. J. Sung, T. H. Chang, M. J. Cheng. 2015. New Coumarin Derivatives and Other Constituents from the Stem Bark of Zanthoxylum avicennae: Effects on Neutrophil Pro-Inflammatory Responses, Int. J. Mol. Sci., 16, 9719-9731.
13 Lee, S. Y., H. C. Ku, Y. H. Kuo, H. L. Chiu, M. J. Su*. 2015. Pyrrolidinyl caffeamide against ischemia/ reperfusion injury in cardiomyocytes through AMPK/AKT pathways, J. Biomed. Sci., 22, 1-9, DOI 10.1186/s12929-015-0125-3.
14 Lin, C. C., C. C. Chen, Y. H. Kuo, J. T. Kuo, K. J. S. Kumar, S. Y. Wang. 2015. 2,3,5-Trimethoxy-4-cresol, an anti-metastatic constituent from the solid-state cultured mycelium of Antrodia cinnamomea and its mechanism, J. Nat. Med., 2015, DOI 10.1007/s11418-015-0916-6.
15 Chen, C. C., Y. H. Kuo, J. J. Cheng, P. J. Sung, C. L. Ni, C. C. Chen, C. C. Shen*. 2015. Three New Sesquiterpene Aryl Esters from the Mycelium of Armillaria mellea, Molecules, 20, 9994-10003.

 

子題1-7 中醫藥結合生醫材料於神經再生之應用

1 Time-course effect of electrical stimulation on nerve regeneration of diabetic rats. PLos One, Accepted.
2 Improved peripheral nerve regeneration in streptozotocin-induced diabetic rats by oral lumbrokinase. American Journal of Chinese Medicine, Accepted.

 

子題1-8 穎殼阿拉伯半乳聚醣癌症免疫療法新藥開發

1 Yang LC, Lu TJ, Hsieh CC, Lin WC. Characterization and immunomodulatory activity of polysaccharides derived from Dendrobium tosaense. Carbohydr Polym. 2014;111:856-63.

 

子題1-9 抗肺癌轉移藥物的研發

1 Lin CY, Chen HJ, Huang CC, Lai LC, Lu TP, Tseng GC, Kuo TT, Kuok QY, Hsu JL, Sung SY, Hung MC, Sher YP. ADAM9 promotes lung cancer metastases to brain by a plasminogen activator-based pathway. Cancer Res. 2014;74:5229-43.

 

子題2-1 牛樟芝新藥開發及品質管控、利用中草藥純化合物樣品庫開發治療骨癌及神經退化之中草藥物

1 Tan TW, Chou YE, Yang WH, Hsu CJ, Fong YC, Tang CH. Naringin suppress chondrosarcoma migration through inhibition vascular adhesion molecule-1 expression by modulating miR-126. Int Immunopharmacol. 2014 ;22:107-14.
2 Horng CT, Shieh PC, Tan TW, Yang WH, Tang CH. Paeonol Suppresses Chondrosarcoma Metastasis throughUp-Regulation of miR-141 by Modulating PKCδ and c-SrcSignaling Pathway. Int J Mol Sci. 2014;15:11760-72.

 

子題2-2 發展茵陳篙治療脂肪肝、肝纖維化與肝癌之植物藥

 

子題2-4 口服糖尿病胰島素取代用藥之開發

1 Chen, J.C., Hsiang, C.Y., Lin, Y.C., and Ho, T.Y.*, Deer antler extract improves fatigue effect through altering the expression of genes related to muscle strength in skeletal muscle of mice. eCAM., 2014;2014:540580.
2 Ho, T.Y., Tang, N.Y., Hsiang, C.Y., and Hsieh, C.L.* 2014. Uncaria rhynchophylla and rhynchophylline improved kainic acid-induced epileptic seizures via IL-1β and brain-derived neurotrophic factor. Phytomedicine 21 (5): 893-900.
3 Ho, T.Y., Lo, H.Y., Chao, D.C., Li, C.C., Liu, J.J., Lin, C., and Hsiang, C.Y.* 2014. Electroacupuncture improves trinitrobenzene sulfonic acid-induced colitis, evaluated by transcriptomic study. Evid. Based Complement. Alternat. Med. 2014: 942196.
4 Lo, H.Y.1, Hsiang, C.Y.1, Li, T.C., Li, C.C., Huang, H.C., Chen, J.C., and Ho, T.Y.* 2014. A novel glycated hemoglobin A1c-lowering traditional Chinese medicinal formula, identified by translational medicine study. PLoS ONE 9(8): e104650. (1 equal contribution)
5 Lo, H.Y.1, Ho, T.Y.1, Li, C.C., Chen, J.C., Liu, J.J., and Hsiang, C.Y.* 2014. A novel insulin receptor-binding protein from Momordica charantia enhances glucose uptake and glucose clearance in vitro and in vivo through triggering insulin receptor signaling pathway. J. Agric. Food Chem. 62 (36): 8952-8961. (1 equal contribution)
6 Hsiang, C.Y., Lin, L.J., Kao, S.T., Lo, H.Y., Chou, S.T., and Ho, T.Y.* 2015. Glycyrrhizin, silymarin, and ursodeoxycholic acid regulate a common hepatoprotective pathway in HepG2 cells. Phytomedicine, in press.
7 Lin, H.C., Lin, C.L., Huang, W.Y., Shangkuan, W.C., Kang, B.H., Chu, Y.H., Lee, J.C., Fan, H.C., and Kao, C.H.* 2015. The use of adjunctive traditional Chinese medicine therapy and survival outcome in patients with head and neck cancer: a nationwide population-based cohort study. QJM-Int. J. Med., in press.
8 Tzeng, C.Y., Lee, Y.C., Ho, T.Y., Chen, Y.I., Hsu, T.H., Lin, J.G., Lee, K.R.*, Chang, S.L.* 2015. Intracellular signalling pathways associated with the glucose-lowering effect of ST36 electroacupuncture in streptozotocin-induced diabetic rats. Acupunct. Med., in press.
  技轉2件―「具血糖調控功能之多胜肽」在瓜科血糖調控保健食品之開發;「苦瓜多胜肽萃取液功效研究」在保健食品之開發

 

子題2-5 中藥苦參對異位性皮膚炎的免疫調控功能與機轉研究(含臨床試驗)

1 Yen H.R., Liu C.J., Yeh C.C. Naringenin suppresses TPA-induced tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells, Chem. Biol. Interact., 2015 Jun, 235():1-9.
2 Yen H.R., Liang K.L., Huang T.P., Fan J.Y., Chang T.T., Sun M.F., Characteristics of traditional Chinese medicine use for children with allergic rhinitis: A nationwide population-based study, INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 2015 Apr, 79(4):591-597.
3 Chang C.M., Chu H.T., Wei Y.H., Chen F.P., Wang S., Wu P.C., Yen H.R., Chen T.J., Chang H.H. The Core Pattern Analysis on Chinese Herbal Medicine for Sjögren's syndrome: A Nationwide Population-Based Study. Sci Rep. 2015 Apr 29;5:9541.
4 Yen H.R., Sun M.F., Lin C.L., Sung F.C., Wang C.C., Liang K.L. Adjunctive traditional Chinese medicine therapy for patients with chronic rhinosinusitis: a population-based study. Int. Forum Allergy Rhinol. 2015 Mar;5(3):240-6.

 

子題G-1 松杉靈芝酒萃物及其有效成份之抗血癌動物模式與抗癌機制研究

 

子題G-2 中草藥抗老化活性評估及分子機制探討、由中草藥平台找尋治療MST3基因嵌入小鼠造成ENaC上升引起的腎臟高血壓

1 HW Lo, M Korivi, YC Tsai, MJ Tang, HL Yang* (2015) Dermato-protective Properties of Ergothioneine through Induction of Nrf2/ARE-mediated Antioxidant Genes in UVA-irradiated Human Keratinocytes. Free Radical Biology and Medicine

 

子題G-3 人疾病之中醫方藥轉譯醫學,臨床研究及新方藥開發